FDA-approved for children 2 months and older with acute graft-versus-host disease (acute GvHD) who did not get better with steroids

Resources andsupport
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Helping your family move forward

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You are not alone

Caring for a child with steroid-refractory acute GvHD can feel like a lot at times. This page has tools to help you stay informed and organized. You will also find helpful support resources.

Have questions? We have answers

Get answers to common questions. Learn more about acute GvHD and RYONCIL.

Explore the Q&A

Helping you stay informed and organized during treatment with RYONCIL

Download and/or print helpful patient information materials to help inform and support your child’s journey with RYONCIL.

Patient brochure cover

Patient Brochure - Understanding What’s Possible With RYONCIL

This guide can help you understand steroid-refractory acute GvHD and what’s possible with RYONCIL.

Independent co-pay assistance foundations document

Independent Co-pay Assistance Foundations

Download to learn more about independent co-pay assistance foundations for eligible patients.


Doctor discussion guide

Doctor Discussion Guide

Know what to expect before, during, and after treatment with RYONCIL.

Personalized support at every step

MyMesoblast is a savings and support hub. Ask your care team how it can help during RYONCIL treatment.

MyMesoblast team members want to help treatment start as soon as possible. They will work with your child’s care team to handle insurance and benefits questions.

Have questions about paying for treatment? If your child has no insurance (or not enough coverage), talk to your care team. MyMesoblast may be able to help.*

*Eligibility rules apply.

Hear from experts in pediatric steroid-refractory acute GvHD

These videos can help inform and empower your child's journey with steroid-refractory acute GvHD.

Watch: Dr Joanne Kurtzberg on treating steroid-refractory aGvHD

Understanding steroid-refractory acute GvHD

Hear doctors discuss the challenges of treating children with steroid-refractory acute GvHD.

Watch: Dr Andrew Harris on discovering what's possible with RYONCIL

Discovering what's possible with RYONCIL

Watch 4 pediatric acute GvHD experts discuss how RYONCIL is making recovery possible for children with acute GvHD who did not get better with steroids

Getting your child the care they need should never feel out of reach

RYONCIL is covered nationwide by most private and government insurance plans. This includes Medicaid in all 50 states, plus Puerto Rico and Washington, DC.

You are not alone

The following organizations provide additional disease information, support, and resources for patients and caregivers.

American Cancer Society

Website: www.cancer.org

Phone: (800) 227-2345

The Aplastic Anemia and MDS International Foundation

Website: www.aamds.org

Phone: (800) 747-2820


Be the Match® Patient Support Center

Website: www.bethematch.org/one-on-one

Phone: 888-999-6743

Email Contact: [email protected]

Blood & Marrow Transplant Information Network (BMT InfoNet)

Website: www.bmtinfonet.org

Phone: 847-433-3313 | Toll Free: 888-597-7674


Bone Marrow and Cancer Foundation (BMCF)

Website: www.bonemarrow.org

Phone: (800) 365-1336

CancerCare

Website: www.cancercare.org

Phone: (866) 552-6729


Good Days

Website: www.mygooddays.org

Phone: (877) 968-7233

GVHD Alliance

Website: www.gvhdalliance.org

Phone: (330) 864-1978


HealthWell Foundation

Website: www.healthwellfoundation.org

Phone: (800) 675-8416

Leukemia and Lymphoma Society

Website: www.lls.org

Phone: (860) 355-3653


National Bone Marrow Transplant Link (nbmtLINK)

Website: www.nbmtlink.org

Phone: 800-LINK-BMT (800-546-5268)

National Organization for Rare Disorders (NORD)

Website: www.rarediseases.org

Phone: (800) 999-6673


NMDP Registry (Be The Match Registry)

Website: www.nmdp.org

Phone: (800) 507-5427

Patient Access Network Foundation (PAN Foundation)

Website: www.panfoundation.org

Phone: (866) 316-7263


Patient Advocate Foundation (PAF)

Website: www.patientadvocate.org

Phone: (800) 532-5274

The Meredith A. Cowden Foundation

Website: www.cowdenfoundation.org

Phone: (330) 864-1978

Need help affording treatment? Download to learn more about independent co-pay assistance foundations for eligible patients.

Independent Co-Pay Assistance FoundationsRYONCIL Copay Assistance brochure

Get support at every step

Learning that your child has steroid-refractory acute GvHD can feel scary. But it’s important to know that you are not alone. Support is available to help your family move forward.

Get support resources

See why recovery is possible with RYONCIL

Learn more about the first and only FDA-approved treatment approved just for children with steroid-refractory acute GvHD.

About RYONCIL

Get the facts about steroid-refractory acute GvHD

Knowledge is power. Learn more about steroid-refractory acute GvHD and how to empower the journey ahead.

Learn more
Indication and Important Safety Information for RYONCIL® (remestemcel-L-rknd)
What is Ryoncil?

RYONCIL is a prescription medicine used to treat a condition called steroid-refractory acute graft versus host disease (SR-aGvHD) in children 2 months and older.

Who should not receive Ryoncil?

Do not receive Ryoncil if you are allergic to DMSO or porcine and bovine proteins (e.g., pigs or cows).

Ryoncil is not recommended if you are pregnant. Talk to your doctor about the risks and benefits of breastfeeding during Ryoncil treatment.

What are the possible serious side effects?
  • Allergic reactions. Serious allergic reactions, including anaphylaxis, can happen during or after infusion. Tell your doctor or nurse right away if you experience signs of an allergic reaction, including fever, rash, hives, low blood sugar, or breathing problems.
  • Infections. Ryoncil is made from human cells using materials from humans and porcine and bovine sources (e.g., pigs, cows). Although all donors and materials are carefully screened and tested, these measures cannot completely eliminate potential risk of transmission of infectious disease.
  • Unusual tissue growth. There is a theoretical risk that Ryoncil could cause growth of tissue in other places, such as bone, cartilage, or fat.
What are the most common side effects?

The most common side effects include infections, fever, bleeding, swelling, stomach pain, high blood pressure, vomiting, irregular heartbeat, diarrhea, rash, joint pain, low blood pressure, cough, and trouble breathing.

What should I tell my doctor before receiving Ryoncil?

Tell your doctor about all your medical conditions, allergies, and if you are pregnant or breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1–800-FDA-1088.

For additional information, see full Prescribing Information.

Indication and Important Safety Information for RYONCIL® (remestemcel-L-rknd)
What is Ryoncil?

RYONCIL is a prescription medicine used to treat a condition called steroid-refractory acute graft versus host disease (SR-aGvHD) in children 2 months and older.

Who should not receive Ryoncil?

Do not receive Ryoncil if you are allergic to DMSO or porcine and bovine proteins (e.g., pigs or cows).

Ryoncil is not recommended if you are pregnant. Talk to your doctor about the risks and benefits of breastfeeding during Ryoncil treatment.

What are the possible serious side effects?
  • Allergic reactions. Serious allergic reactions, including anaphylaxis, can happen during or after infusion. Tell your doctor or nurse right away if you experience signs of an allergic reaction, including fever, rash, hives, low blood sugar, or breathing problems.
  • Infections. Ryoncil is made from human cells using materials from humans and porcine and bovine sources (e.g., pigs, cows). Although all donors and materials are carefully screened and tested, these measures cannot completely eliminate potential risk of transmission of infectious disease.
  • Unusual tissue growth. There is a theoretical risk that Ryoncil could cause growth of tissue in other places, such as bone, cartilage, or fat.
What are the most common side effects?

The most common side effects include infections, fever, bleeding, swelling, stomach pain, high blood pressure, vomiting, irregular heartbeat, diarrhea, rash, joint pain, low blood pressure, cough, and trouble breathing.

What should I tell my doctor before receiving Ryoncil?

Tell your doctor about all your medical conditions, allergies, and if you are pregnant or breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1–800-FDA-1088.

For additional information, see full Prescribing Information.