Hearing that steroids are not working well enough can feel overwhelming. But it does not mean hope is lost. Even during difficult moments, a path to recovery is still possible.
Learn about treatment
RYONCIL (Rye-ON-sill) is the first and only FDA-approved cell therapy for children 2 months of age and older with acute GvHD that did not get better with steroids. RYONCIL is also the only approved steroid-refractory acute GvHD treatment for children under the age of 12.
RYONCIL is a special medicine made from living cells. This is called cell therapy. It’s approved just for children with steroid-refractory acute GvHD. It is for children 2 months through 17 years of age.
Explore treatment with RYONCIL
Specifically studied in children
See results from a clinical trial studying children 2 months and older.
Results with RYONCIL
Know what to expect during treatment
RYONCIL is a proven cell therapy with a clear treatment schedule.
Treatment with RYONCIL
Share your RYONCIL success story
If you've already seen what's possible with RYONCIL, your experience could help other families still searching for answers.
Get started“The majority responded and improved on RYONCIL.”
Dr Joanne Kurtzberg
acute GvHD expert
“It’s shown to be effective with this 4-week course.”
Dr Andrew Harris
acute GvHD expert
“When you inject the cells…they modulate the immune system in a way to decrease the inflammation.”
Dr Paul Carpenter
acute GvHD expert
“Sending a child home is a celebration, and we were able to celebrate that.”
Dr Prakash Satwani
acute GvHD expert
Prepare for your next care team conversation
Know what questions to ask during your next appointment.
RYONCIL is a prescription medicine used to treat a condition called steroid-refractory acute graft versus host disease (SR-aGvHD) in children 2 months and older.
Do not receive Ryoncil if you are allergic to DMSO or porcine and bovine proteins (e.g., pigs or cows).
Ryoncil is not recommended if you are pregnant. Talk to your doctor about the risks and benefits of breastfeeding during Ryoncil treatment.
The most common side effects include infections, fever, bleeding, swelling, stomach pain, high blood pressure, vomiting, irregular heartbeat, diarrhea, rash, joint pain, low blood pressure, cough, and trouble breathing.
Tell your doctor about all your medical conditions, allergies, and if you are pregnant or breastfeeding.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1–800-FDA-1088.
For additional information, see full Prescribing Information.
RYONCIL is a prescription medicine used to treat a condition called steroid-refractory acute graft versus host disease (SR-aGvHD) in children 2 months and older.
Do not receive Ryoncil if you are allergic to DMSO or porcine and bovine proteins (e.g., pigs or cows).
Ryoncil is not recommended if you are pregnant. Talk to your doctor about the risks and benefits of breastfeeding during Ryoncil treatment.
The most common side effects include infections, fever, bleeding, swelling, stomach pain, high blood pressure, vomiting, irregular heartbeat, diarrhea, rash, joint pain, low blood pressure, cough, and trouble breathing.
Tell your doctor about all your medical conditions, allergies, and if you are pregnant or breastfeeding.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1–800-FDA-1088.
For additional information, see full Prescribing Information.
